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Dr. Kara Fitzgerald | New Frontiers in Functional Medicine, Longevity, Epigenetics
Dr. Kara Fitzgerald | New Frontiers in Functional Medicine, Longevity, Epigenetics
Author: Dr. Kara Fitzgerald
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Welcome to New Frontiers in Functional Medicine, Longevity & Epigenetics™ where I interview the best minds in functional medicine to discuss the science and research behind medicine, longevity, epigenetics, and so much more. Expect thought-provoking ideas, new research, lots of clinical pearls for practitioners, and step-change information for clinicians and patients. Join us! ~DrKF
Copyright © 2025 by KF Education and Consulting, LLC
All Rights Reserved
Copyright © 2025 by KF Education and Consulting, LLC
All Rights Reserved
202 Episodes
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Dr. Kara Fitzgerald talks with Sergey Young, founder of the Longevity Vision Fund and XPRIZE board member, about the future of aging medicine. Hear how AI, wearables, new diagnostics, and early screening are making longevity solutions more practical, affordable, and clinically relevant for functional medicine practitioners.
Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.
GUEST DETAILS
Sergey Young is a longevity investor, author, and visionary committed to extending healthy lifespans for one billion people. He co-founded the BOLD Longevity Growth Fund, wrote the bestseller The Science and Technology of Growing Young, and serves on the boards of XPRIZE and AFAR.
Website: https://sergeyyoung.com/
Follow Sergey: @sergeyyoung200
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Younger You book: https://tinyurl.com/mr4d9tym
Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw
Hair loss is more than cosmetic. In this episode of New Frontiers in Functional Medicine, Dr. Kara Fitzgerald explores new research on the OS-01 peptide and its role in targeting senescent cells. Learn how peptide therapy compares to minoxidil, and how hormones, thyroid health, stress, UV exposure, and the scalp microbiome all play a role in thinning hair. Carolina Reis Oliveira, PhD, co-founder of OneSkin, shares insights on how polyphenols, prebiotics, and integrative strategies can support healthier growth.
Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.
GUEST DETAILS
Carolina Reis Oliveira, PhD - OneSkin Co-Founder & CEO
Carolina Reis Oliveira, PhD, is the CEO and co-founder of OneSkin and an advocate for healthy aging. With a doctorate in immunology, she moved from Brazil to Silicon Valley to pursue her vision of using science to prevent age-related diseases. At OneSkin, she leads pioneering research on aging biology, including the development of the proprietary OS-01 peptide, the first scientifically proven to reverse skin’s biological age.
THANKS TO OUR SPONSOR
OneSkin: http://oneskin.co/DRKARA
EXCLUSIVE OFFER FOR NEW FRONTIERS LISTENERS
Interested in reclaiming your roots and addressing hair thinning? Visit https://oneskin.co/DRKARA for 15% off your purchase of OneSkin’s OS-01 HAIR peptide scalp serum.
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Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz
YouTube: https://tinyurl.com/hjpc8daz
Instagram: https://www.instagram.com/drkarafitzgerald/
Facebook: https://www.facebook.com/DrKaraFitzgerald/
DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb
Younger You book: https://tinyurl.com/mr4d9tym
Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw
Have you ever struggled to understand why some patients just don’t respond as expected, even when you’re following all the usual gut protocols? In this episode, I sat down with Dr. Tom Fabian, who breaks down the latest insights from StoolOMX and GI-MAP testing and shows us how to put them into practice for our most complex cases.
We dive into how identifying specific types of inflammation, bile acid patterns, and microbial imbalances can guide more precise interventions, whether it’s introducing fiber, addressing biofilms, or supporting secondary bile acid production. Dr. Fabian makes the science practical, helping us see not just what’s happening in the gut, but what to do about it in real-world clinical settings. ~DrKF
FOLLOW ALONG WITH THE CONVERSATION!
Curious about the StoolOMX Add-On to GI-MAP? Head to http://tinyurl.com/StoolOMX to download the StoolOMX Reference Guide to better understand results and create effective, actionable protocols
Listeners, join me and Dr. Tom Fabian for a free webinar on October 23rd 2025 and get your questions answered on all things on all things bile acids, pattern recognition on functional stool testing and precision-based interventions for optimal gut health and longevity. Register here: https://tinyurl.com/ydzsh6y6
Check out the show notes at www.drkarafitzgerald.com/fxmed-podcast/ for all the relevant links and resources.
GUEST DETAILS
Thomas Fabian, PhD, CNTP
Email: tom.fabian@diagnosticsolutionslab.com
Dr. Tom Fabian, PhD, is a translational scientist focused on applying microbiome research in functional and integrative medicine. He serves as a consultant and science advisor with Diagnostic Solutions Laboratory, sits on the Science Advisory Board at Designs for Health, and is a certified Nutrition Therapy Practitioner.
THANKS TO OUR SPONSOR
Diagnostic Solutions Laboratory: https://tinyurl.com/2shv9jth
Phone: 877-485-5336
CONNECT with DrKF
Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz
YouTube: https://tinyurl.com/hjpc8daz
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Facebook: https://www.facebook.com/DrKaraFitzgerald/
DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb
Younger You book: https://tinyurl.com/mr4d9tym
Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw
Can functional medicine unlock the secrets to healthy aging? In this special preview of the Functional Medicine is Longevity Medicine™ Masterclass happening on September 17- September 19, 2025, Dr. Kara Fitzgerald sits down with three leading voices in medicine and research:
- Dr. Bob Rountree: functional medicine pioneer in integrative approaches to health
- Dr. Dale Bredesen: internationally recognized expert on Alzheimer’s prevention and reversal
- Dr. Charles Serhan: Harvard researcher on inflammation resolution and aging biology
Together, they explore how functional medicine reframes longevity by addressing root causes, supporting cognitive health, and resolving chronic inflammation.
Whether you’re a clinician, health professional, or simply passionate about living longer and healthier, this conversation offers a glimpse into the science and practical applications that are transforming longevity medicine.
WATCH NOW TO LEARN:
- Why functional medicine is central to extending healthspan
- The latest insights on Alzheimer’s prevention and brain health
- How inflammation resolution impacts aging and chronic disease
- What to expect in the full Functional Medicine is Longevity Medicine™ Masterclass
Learn more & register for the Masterclass here: www.functionalmedicineislongevitymedicine.com
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Biotics Research: https://www.bioticsresearch.com/
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Vibrant Wellness: https://www.vibrant-wellness.com/
EXCLUSIVE OFFERS FROM OUR SPONSORS
OneSkin: Get 15% off OneSkin with the code DRKARA at http://oneskin.co/DRKARA
Discover why MitoQ’s mitochondria-targeting is a critical step for your healthspan and longevity strategy. https://tinyurl.com/4f8t7jt6
It was a pleasure to sit down with Dr. Nir Barzilai for a conversation that turned out to be both lively and thought-provoking. His decades of research on centenarians, biological age, and the hallmarks of aging have shaped how we think about longevity—and what’s possible when we start targeting aging itself, not just individual diseases.
We get into the science behind why some people live 20–30 years longer and healthier, and what it means to measure the biological age of individual organs. But we also hit a few sparks—especially when it comes to nutraceuticals and the role of metformin in prevention. I don’t agree with everything you’ll hear, and I followed up with Dr. Barzilai afterward to unpack some of the more provocative claims. We may just need a second round for this one... stay tuned.
Check out the show notes at www.drkarafitzgerald.com/fxmed-podcast/ for all the relevant links and resources. ~DrKF
Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.
GUEST DETAILS
Nir Barzilai M.D.
Director of the Einstein Institute for Aging Research
Professor of Medicine and Genetics
President of the Academy for Health & Lifespan Research
Website: https://einsteinmed.edu/faculty/484/nir-barzilai
Email: nir.barzilai@einsteinmed.edu
Dr. Nir Barzilai is a pioneer in aging science, known for his work on centenarians, the biology of aging, and the TAME trial. He is Director of the Institute for Aging Research at Albert Einstein College of Medicine and author of Age Later and has published over 330 papers.
THANKS TO OUR SPONSORS
DIAMOND
DUTCH: https://dutchtest.com/for-providers
Biotics Research: https://www.bioticsresearch.com/
GOLD
Vibrant Wellness: https://www.vibrant-wellness.com/
OneSkin: http://oneskin.co/DRKARA
EXCLUSIVE OFFERS FROM OUR SPONSORS
Find out why MitoQ’s mitochondria-targeting is a critical step for your healthspan and longevity strategy. https://tinyurl.com/4f8t7jt6
OneSkin: Get 15% off OneSkin with the code DRKARA at oneskin.co/DRKARA
CONNECT with DrKF
Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz
YouTube: https://tinyurl.com/hjpc8daz
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Facebook: https://www.facebook.com/DrKaraFitzgerald/
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Younger You book: https://tinyurl.com/mr4d9tym
Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw
I’ve been watching the science behind Calocurb evolve over the last year, and I have to say—this is one of the most exciting clinical tools I’ve seen emerge in the metabolic space in quite some time. A hops-derived compound that stimulates endogenous GLP-1, CCK, and PYY—without a prescription or injection? That’s a big deal, especially for patients struggling with appetite regulation, weight plateaus, or the aftermath of GLP-1 discontinuation.
In this episode, I sit down with Sarah Kennedy, founder of New Zealand-based Calocurb, to talk about the years of government-funded research that led to this discovery, the remarkable clinical outcomes they’ve seen so far, and how I’ve personally used it in my practice with excellent results. If you’re looking for science-backed, natural strategies to support appetite control, fasting, or GLP-1 transitions—this one’s worth a listen. ~DrKF
Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.
GUEST DETAILS
Sarah Kennedy, Founder and CEO of Calocurb Ltd.
Email: sarah.kennedy@calocurb.com
LinkedIn: https://www.linkedin.com/in/sarah-kennedy-0a840b13/
Sarah Kennedy, BVSc, is a veterinarian and health industry leader with 20+ years in nutrition science and innovation. Now CEO of Calocurb, she brings a unique perspective on natural GLP-1 activation—bridging plant-based research, gut physiology, and clinical application.
THANKS TO OUR SPONSOR: Calocurb
EXCLUSIVE OFFER FOR NEW FRONTIERS LISTENERS
Manage cravings and feel full faster with Calocurb, a 100% natural capsule that supports healthy weight management. Visit http://calocurb.com/drkara10 and use code DRKARA10 at checkout.
CONNECT with DrKF
Join Dr. Kara Fitzgerald and leading experts *LIVE on Sept 17–19, 2025* for a free virtual Masterclass on redefining healthcare & longevity through the lens of science-backed, systems-based approach. Register now: https://www.functionalmedicineislongevitymedicine.com/
Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz
YouTube: https://tinyurl.com/hjpc8daz
Instagram: https://www.instagram.com/drkarafitzgerald/
Facebook: https://www.facebook.com/DrKaraFitzgerald/
DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb
Younger You book: https://tinyurl.com/mr4d9tym
Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw
In this very special episode, I have the privilege of turning the tables on Dr. Kara Fitzgerald as we celebrate 10 years of the New Frontiers podcast. I’ve been honored to walk alongside Kara on much of this journey—as a colleague, a collaborator, a mentee, and a friend—and it’s been incredible to witness the evolution of both her work and the field itself.
Together, we reflect on the stories, science, and people who have shaped this podcast—and the remarkable growth of epigenetics, personalized medicine, and functional medicine along the way. From early conversations around methylation and aging to hosting pioneers like Dr. Jeff Bland, Dr. Sidney Baker, and Dr. Charles Serhan, New Frontiers has become a living archive of how this field has moved forward.
As we talked about during the conversation: “Everybody is a piece of this ecosystem, and everybody has their role... It’s really cool to be part of that community.” This episode is a celebration of that collective journey—and a look at where we’re headed next. ~Romilly Hodges MS CNS
Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.
THANKS TO OUR SPONSORS
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Biotics Research: https://www.bioticsresearch.com/
DUTCH: https://dutchtest.com/for-providers
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Vibrant Wellness: https://www.vibrant-wellness.com/
TimeLine Nutrition: https://tinyurl.com/bdzx2xms
EXCLUSIVE OFFERS FROM OUR SPONSORS
OneSkin: Get 15% off OneSkin with the code DRKARA at http://oneskin.co/DRKARA
Find out why MitoQ’s mitochondria-targeting is a critical step for your healthspan and longevity strategy. https://tinyurl.com/4f8t7jt6
CONNECT with DrKF
Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz
YouTube: https://tinyurl.com/hjpc8daz
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Younger You Group Program: https://tinyurl.com/4hvusavw
Younger You book: https://tinyurl.com/mr4d9tym
Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw
This is a really exciting conversation with Dr. Davide D’Amico from Timeline, where we’re taking a closer look at Urolithin A and heart health. It should come as no surprise that this mitochondrial wonderkin of a nutrient is showing promise here—especially when you consider that 40% of the heart’s weight is mitochondria. That’s an extraordinary factoid, and one that really shifts how we think about aging in the cardiovascular system.
What’s particularly compelling in this new preclinical research is that restoring mitochondrial function may do more than just improve ejection fraction. It may also have ripple effects on other hallmarks of aging—like chronic inflammation, cellular stress signaling, and impaired autophagy. I’m thrilled Timeline is continuing to invest in both preclinical and clinical research on this front—and yes, I’m totally nerding out over what they’re up to. ~DrK
Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.
GUEST DETAILS
Davide D'Amico, PhD: Director of Discovery and Translational Research at Timeline.
With over 15 years of experience in mitochondrial and aging biology, he contributed to developing Urolithin A as a science-backed, clinically validated nutritional product to enhance mitochondrial and muscle health.
THANKS TO OUR SPONSOR
Timeline: http://Timeline.com/kara10
Email: care@timeline.com
EXCLUSIVE OFFER FOR NEW FRONTIERS LISTENERS
Mitopure is making impressive strides for cellular health and longevity. Get 10% off your first order at http://Timeline.com/kara10 with code Kara10.
CONNECT with DrKF
Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz
YouTube: https://tinyurl.com/hjpc8daz
Instagram: https://www.instagram.com/drkarafitzgerald/
Facebook: https://www.facebook.com/DrKaraFitzgerald/
DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb
Younger You book: https://tinyurl.com/mr4d9tym
Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw
This episode is a little different from what we usually cover on New Frontiers, but it’s one I couldn’t wait to bring to you. I’ve been thinking a lot about how we—as clinicians—are supposed to keep up in this era of high-throughput technology. We’re swimming in data: labs, multi-omics, diet logs… and an ever-growing stream from wearables. There’s just so much coming at us, and too often, we’re awash in a sea of information without adequate interpretive power.
That’s why this conversation with Dr. Rana el Kaliouby felt so important. She’s not just an AI scientist—she’s a visionary and a total badass. She’s building technology that doesn’t just process data, but actually helps us become better clinicians and better humans. We get into the ethics, the potential, the parenting implications—and yes, a personal story about a tragedy in my own hometown that made this all hit very close to home. This one’s powerful, and I hope it sparks the same questions and inspiration for you as it did for me. ~DrKF
TRIGGER WARNING
This episode touches on sensitive topics, including gun violence and suicide, in the context of empathy, mental health, and technology. If you or someone you know is struggling, please seek help. We share this with care and hope it offers support and perspective.
Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.
GUEST DETAILS
Dr. Rana el Kaliouby: http://www.ranaelkaliouby.com
Managing Partner, Blue Tulip Ventures: http://www.bluetulip.vc
Host, Pioneers of AI Podcast: https://www.pioneersof.ai/
Author of Girl Decoded
Dr. Rana el Kaliouby is an Egyptian-American AI scientist, entrepreneur and investor. She is co-founder and Managing Partner of Blue Tulip Ventures, where she invests in startups building Human-Centric AI, and host of the Pioneers of AI podcast. Prior to that, Rana founded her company Affectiva out of MIT, where she pioneered the field of Emotion AI, and successfully exited the company in 2021. She holds a Ph.D. from the University of Cambridge and a Post Doctorate from MIT.
THANKS TO OUR SPONSORS
DIAMOND
Biotics Research: https://www.bioticsresearch.com/
DUTCH: https://dutchtest.com/for-providers
GOLD
Vibrant Wellness: https://www.vibrant-wellness.com/
TimeLine Nutrition: https://tinyurl.com/bdzx2xms
EXCLUSIVE OFFERS FROM OUR SPONSORS
OneSkin: Get 15% off OneSkin with the code DRKARA at http://oneskin.co/DRKARA
Find out why MitoQ’s mitochondria-targeting is a critical step for your healthspan and longevity strategy. https://tinyurl.com/4f8t7jt6
CONNECT with DrKF
Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz
YouTube: https://tinyurl.com/hjpc8daz
Instagram: https://www.instagram.com/drkarafitzgerald/
Facebook: https://www.facebook.com/DrKaraFitzgerald/
DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb
Younger You Group Program: https://tinyurl.com/4hvusavw
Younger You book: https://tinyurl.com/mr4d9tym
Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw
In many ways, the legal side of functional medicine can feel like the Wild West—uncertain, unregulated, and full of risks. The reality is, we all want to have our practices legally buttoned up, but navigating the legal landscape can feel overwhelming—and expensive. What Scott Rattigan, creator of Functional Lawyer, shares in this episode is a real game-changer. He not only breaks down the complexities of the legal side of things but also offers real solutions for us—solutions that can make sure we're covered without the stress and uncertainty that often comes with it. Whether you're just starting out or growing your established practice, you're going to get actionable insights on how to avoid common legal pitfalls, protect your practice, and actually move forward with confidence. It’s a topic that’s been an unmet need for so long, and I'm so excited to bring this to you. ~DrKF
Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.
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Download 5 Essential Legal Documents for Every Functional or Integrative Medicine Practice: https://www.functionallawyer.com/resource-downloads
GUEST DETAILS
Scott Rattigan, JD
Founder: Functional Lawyer: https://www.functionallawyer.com/kf
Co-founder: Origins Incubator - https://www.originsincubator.com/
The Junto Podcast Playlist: https://fxmedlaw.com/junto-youtube
LinkedIn: https://www.linkedin.com/in/scott-rattigan/
Email: info@functionallawyer.com
Phone: 941-229-0928
Scott Rattigan, JD, is the founder of Functional Lawyer, offering flat-rate legal solutions to help practitioners protect their licenses and grow their businesses. Inspired by helping his wife build her functional medicine practice, Scott provides high-quality legal support for health coaches, doctors, and more. He’s an attorney, internationally recognized speaker, host of The Junto with Scott Rattigan, bestselling author of The Practice of Telemedicine, and co-founder of the practice success software ReveliaDx.
THANKS TO OUR SPONSOR
Functional Lawyer: https://www.functionallawyer.com/kf
CONNECT with DrKF
Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz
YouTube: https://tinyurl.com/hjpc8daz
Instagram: https://www.instagram.com/drkarafitzgerald/
Facebook: https://www.facebook.com/DrKaraFitzgerald/
DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb
Younger You book: https://tinyurl.com/mr4d9tym
Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw
I’ve been looking forward to sharing this conversation with you because it’s one I’m truly passionate about. Today, we’re diving into the DunedinPACE epigenetic clock with one of its creators, the brilliant Dan Belsky. It’s a tool I use regularly with my patients, and one that’s transforming how we approach aging and interventions. While this show is a bit more technical than usual, the science is fascinating, and the real-world applications are incredibly valuable. This isn’t just about theory—it’s about practical insights that can change how we measure aging and track the effectiveness of the treatments we offer. Stick with us, and you’ll walk away with actionable knowledge that can make a difference in your practice. ~DrKF
Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.
GUEST DETAILS
Daniel W Belsky, PhD
Website: www.belskylab.com
THANKS TO OUR SPONSORS
DIAMOND
DUTCH: https://dutchtest.com/for-providers
Biotics Research: https://www.bioticsresearch.com/
GOLD
TimeLine Nutrition: https://tinyurl.com/bdzx2xms
Vibrant Wellness: https://www.vibrant-wellness.com/
EXCLUSIVE OFFERS FROM OUR SPONSORS
OneSkin: Get 15% off OneSkin with the code DRKARA at https://www.oneskin.co/DRKARA
Why MitoQ’s mitochondria-targeting is a critical step for your healthspan and longevity strategy. https://tinyurl.com/4f8t7jt6
CONNECT with DrKF
Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz
YouTube: https://tinyurl.com/hjpc8daz
Instagram: https://www.instagram.com/drkarafitzgerald/
Facebook: https://www.facebook.com/DrKaraFitzgerald/
DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb
Younger You Group Program: https://tinyurl.com/4hvusavw
Younger You book: https://tinyurl.com/mr4d9tym
Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw
What if a human trial of over 1200 patients showed improved mobility and reduced pain in osteoarthritis (OA) patients using a natural combination of boswellia and celery seed extract? What if a second follow-up randomized, placebo-controlled human trial found that within 90 days, this same combination increased OA patients' ability to perform a walk test by over 50%, reduced markers of cartilage degeneration by half and increased markers of cartilage regeneration by half. This is what the research team at Calroy Health Sciences have discovered, putting a tremendous amount of work and financing into studying the effects of the uniquely-developed Cartigenix-HP. Not only that, increased joint space at the end of the trial was clearly visible via radiography, and 90% of the intervention group did not need any "rescue" pharmaceutical medication at the end of the 90 day period (compared with only 20% of the placebo group) and this effect was sustained beyond the end of the trial. I have to say, I am impressed and excited about the potential for this new product to help my patients and I am thinking about other applications like OA prevention and osteoporosis! Listen in to find out more. ~ DrKF
Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.
GUEST DETAILS
Kiran Krishnan, Microbiologist
Kiran Krishnan is a research microbiologist and a health and wellness expert who aims to make complex information understandable to all. He has founded a number of successful health and supplement companies over the last 20 years including co-founding and leading Microbiome Labs, the preeminent, microbiome therapeutics focused brand among healthcare professionals. He is currently a co-founder and partner in 3 other companies that aim to revolutionize wellness care and an advisor to Calroy Health Sciences. He has conducted and published several research studies in scientific journals, has published chapters in scientific textbooks/references books, has global patents and is a sought after speaker on human health and the microbiome.
THANKS TO OUR SPONSOR
Go to Calroy.com/drkf for exclusive resources and discounts on Cartigenix HP.
CONNECT with DrKF
Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz
YouTube: https://tinyurl.com/hjpc8daz
Instagram: https://www.instagram.com/drkarafitzgerald/
Facebook: https://www.facebook.com/DrKaraFitzgerald/
DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb
Younger You book: https://tinyurl.com/mr4d9tym
Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw
We’ve all had patients struggling with chronic conditions like long COVID, fibromyalgia, Lyme disease, and chronic fatigue. Despite all the tools in our functional medicine toolkit, there’s still something missing. How can we truly help them? I’m excited to have Ashok Gupta back on the New Frontiers podcast to offer a new take on healing from chronic illness. He explains that many chronic diseases stem from a malfunction in the brain's threat detection system, where the body overreacts to perceived threats, triggering immune, nervous system, or mood responses, creating a vicious cycle. Ashok shares how retraining the brain and calming the nervous system can reset the body’s response to chronic stress and presents the growing body of research supporting the Gupta Program, including new subjective measurements like CRP showing its impact. What excites me most is the potential for this approach to help some of my toughest-to-treat patients. With more studies emerging, I’m increasingly hopeful this could be a game-changer. It’s a conversation you won’t want to miss! ~DrKF
Check out the show notes at https://tinyurl.com/2t55s3y3 for the full list of links and resources.
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GUEST DETAILS
Ashok Gupta
Email: ashokguptaprogram@gmail.com
https://guptaprogram.com/
Ashok Gupta is an internationally recognized speaker, filmmaker, and health practitioner who specializes in supporting individuals with chronic illness. After overcoming ME (Chronic Fatigue Syndrome) through his own neuroplasticity research, Ashok developed the Gupta Program in 2007 to help others recover. He has published several medical papers and continues to research chronic conditions, with recent studies demonstrating the effectiveness of the Gupta Program. Ashok is dedicated to advancing holistic approaches to healing and improving outcomes for those facing chronic illness.
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What if the key to reversing chronic disease, slowing cognitive decline, and boosting energy lies in the tiny powerhouses inside your cells—and we’ve finally found a way to protect them?
We know mitochondria power our cells, but did you know they also create oxidative stress as they generate energy? Protecting mitochondrial health is critical—but most antioxidants can't reach inside the mitochondria where protection is needed most—until now. MitoQ, a scientifically advanced, mitochondria-targeted antioxidant developed by visionary researchers in New Zealand penetrates mitochondria up to 90%, offering protection where it's needed most.
In this episode with Dr. Siobhan Mitchell, we dive into how MitoQ is transforming the way we tackle chronic disease, inflammation, and cognitive decline. From improving heart health to supporting brain function, MitoQ is changing the game. It’s something I’m using personally and recommending to most of my patients. Listen in to discover how this powerful tool can help you support your patients at the cellular level—before symptoms even appear. ~DrKF
Check out the show notes at https://tinyurl.com/2t55s3y3 for the full list of links and resources.
GUEST DETAILS
Dr Siobhan Mitchell, PhD., MitoQ Chief Scientific Officer
Email: smitchell@mitoq.com
Holding a PhD in neuroscience from SUNY Albany, Siobhan Mitchell has also completed a post-doctoral fellowship on brain aging at the University of Washington. She has over 15 years of clinical research experience, seven patents on mood and cognitive food products, and has authored over 50 papers on aging, brain health, nutrition, metabolic health and more.
With a personal passion for brain aging research, Siobhan has worked on metabolic and skin health, appetite, sports physiology and of cellular health –which she now focuses on as the Chief Scientific Officer for research-backed cellular health company, MitoQ – creators of the world’s first mitochondria-targeted antioxidant.
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CustomerService@mitoq.com
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Join me for a fascinating conversation around an exciting breakthrough in dementia detection that’s offering real hope for early intervention. Dr. Hans Frykman, Chief Scientific Officer at Neurocode Laboratories, is here to share groundbreaking insights into cutting-edge biomarkers that can identify pathology associated with Alzheimer's disease before symptoms even appear. What’s even more fascinating is how these same tools are revealing neuroinflammation caused by infections, including COVID, Lyme disease, and mold exposure—issues that are incredibly relevant in functional medicine today. The assays Dr. Frykman and his team have developed, and continue to research, are transforming the way we think about diagnosing and addressing neurodegeneration. We’re talking about a potential game-changer that allows us to intervene earlier, reverse damage, and ultimately improve the trajectory of these conditions. This is an extraordinary time in science and medicine, and the work we’re discussing today is at the forefront of it all. Don’t miss out on how this could reshape your practice. ~DrKF
Check out the show notes at https://tinyurl.com/2t55s3y3 for the full list of links and resources.
GUEST DETAILS
Dr. Hans Frykman, MD PhD FRCPC
hfrykman@neurocode.com
Hans Frykman MD, Ph.D., FRCPC is the founder, CEO, and medical director of BC Neuroimmunology Lab located in the UBC hospital on the University of BC campus in Vancouver BC. He is the medical director for Lykke Lab a genetics laboratory also on the University of BC campus. Also, he is the CSO for Neurocode Lab Inc. in Bellingham WA, a high-complexity, specialty lab focused on neuroimmunology and biomarkers in neurodegeneration. Dr. Frykman has a clinical faculty position at the University of British Columbia, Faculty of Medicine, Division of Neurology.
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Why MitoQ’s mitochondria-targeting is a critical step for your healthspan and longevity strategy.https://tinyurl.com/4f8t7jt6
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We’re witnessing an exciting shift in how we understand gut health and disease—and it’s all thanks to the powerful metabolites produced by the microbiome, like short-chain fatty acids (SCFAs) and secondary bile acids. In today’s episode, Dr. Tom Fabian shares groundbreaking insights into how these postbiotics influence intestinal barrier integrity, immune balance, and even muscle regeneration. These compounds are also connected to key processes like glucose metabolism and healthy aging. What’s truly fascinating is how this science is opening up new frontiers in treating IBS, metabolic conditions, and chronic gut issues. With the upcoming launch of Diagnostic Solution Laboratories’ StoolOMX test, an add-on to the GI-MAP, we now have a tool to measure these metabolites in clinical practice, making personalized and effective treatments more attainable. This is a pivotal moment in functional medicine that you don’t want to miss. ~DrKF
FOLLOW ALONG WITH THE CONVERSATION!
Get the Updated GI-MAP® Guide with StoolOMX™ Insights! The new GI-MAP® Guide now includes StoolOMX™ insights on bile acids and short-chain fatty acids, enhancing your understanding of IBS, IBD, and gut motility. Refine treatment strategies and optimize patient care with this essential resource. Download now! https://tinyurl.com/5ehysjp7
Check out the show notes at https://tinyurl.com/2t55s3y3 for the full list of links and resources.
GUEST DETAILS
Thomas Fabian, PhD, CNTP
Email: tom.fabian@diagnosticsolutionslab.com
Dr. Fabian is a leading expert on the role of the microbiome in health, immune function, chronic disease, and aging. As a translational scientist, his primary focus is on the clinical application of microbiome research in the integrative and functional medicine space. He received his PhD in molecular biology from the University of Colorado, Boulder, and has worked as a biomedical researcher in the biotechnology industry, and more recently, as a consultant in the microbiome testing field. Currently, Dr. Fabian serves a consultant and science advisor with Diagnostic Solutions Laboratory, and he is also a Science Advisory Board member with Designs for Health. In addition, he is certified as a Nutrition Therapy Practitioner by the Nutrition Therapy Institute in Denver.
THANKS TO OUR SPONSOR
Diagnostic Solutions Laboratory: https://www.diagnosticsolutionslab.com/
Phone: 877-485-5336
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It’s very difficult (often impossible) to completely avoid many of the environmental toxins that can cause harm - like air pollution and forever chemicals that contaminate our water and food supply. But Drs. Bob and Rosalind Wright at Mount Sinai have a hopeful solution to this dilemma. They are pioneering the study of “resiliency factors,” not just “risk factors,” that can offset the risks of harmful exposures. It’s a fresh and welcome take on exposomics that I am very excited to share with you. For instance - did you know that omega-3 intake during pregnancy can protect against the development of asthma in the child, even if the child is exposed to known risk factors for asthma? Or that positive relationships (ones that create a sensitive, positive, caregiving environment) have been shown to potentially mitigate the effects of environmental toxins? As a practitioner, I am always looking to empower patients with real solutions to the health challenges we inevitably face and I hope you enjoy this conversation as much as I did. ~DrKF
Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.
GUEST DETAILS
Dr. Rosalind J. Wright, MD, MPH and Robert O. Wright, MD, MPH
Icahn School of Medicine at Mount Sinai https://icahn.mssm.edu/
Dr. O. Robert Wright is the Ethel H. Wise Chair of Environmental Medicine at Mount Sinai and co-founder of the Institute for Exposomic Research. His research links environmental exposures, like those tracked in the PROGRESS cohort, with the developmental origins of diseases.
Dr. Rosalind J. Wright is Dean for Public Health at Icahn School of Medicine and Co-Director of the Institute for Climate Change, Environmental Health, and Exposomics. A pioneer in environmental health, she studies how early-life exposures influence chronic diseases and has been NIH-funded for over 23 years. She also mentors the next generation of clinical scientists.
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Try QUALIA NAD+ for up to 50% off! Visit https://www.qualialife.com/kara15 and use code KARA15 at checkout for an additional 15% off your entire purchase.
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Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz
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Join me and Dr. Colleen Cutcliffe, my brilliant friend, scientist, and the powerhouse CEO of Pendulum, for our deepest dive yet into all things Akkermansia. This free-flowing conversation will take your understanding of this extraordinary strain to a whole new level. We’ll explore Akkermansia’s pivotal role in metabolic health—think cravings, weight regulation, A1C—and why we’re deficient in the first place. Plus, we’ll discuss its connection to stress, anxiety, and even neurodegenerative diseases. We’ll also dive into the hotly debated topic of Akkermansia’s impact on MS, unpacking both sides of the controversy. And, we’ll touch on its promising influence on hormonal balance, from infertility to menopause.
As someone who's deeply invested in science, I’m personally bullish on Akkermansia and trust Pendulum’s products as part of my own foundational health stack. With groundbreaking science and fresh insights, this episode will change the way you approach your practice. ~DrKF
Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.
GUEST DETAILS
Colleen Cutcliffe, PhD, Co-Founder and CEO of Pendulum Therapeutics
Colleen Cutcliffe is the Chief Executive Officer and co-founder of Pendulum. She has more than 25 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotechnology. Prior to starting Pendulum, Colleen was the senior manager of biology at Pacific Biosciences and a scientist at Elan Pharmaceuticals. Colleen completed her postdoctoral studies at Northwestern’s Children’s Memorial Hospital. Colleen received her Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and her B.A. in Biochemistry from Wellesley College.
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Not a practitioner but ready to try Pendulum probiotics for yourself? Take 20% off your first membership order with code KARA20 at checkout. https://tinyurl.com/2tjp3jb4
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For many struggling with depression, the message they often hear from traditional care is "just live with it" or "there’s nothing more we can do." In today’s episode, we’re challenging that narrative. I’m joined by Dr. Achina Stein and Silvia Covelli from the Healing Depression Project - a groundbreaking residential treatment and research program. Dr. Stein, a functional psychiatrist, and Silvia, who’s personally battled chronic depression, are offering a fresh approach to treatment-resistant depression. Their in-residence program, launching in March, takes a whole-person approach—integrating nutrition, lifestyle changes, trauma healing, and community support. And with research built into the program, they’re not just helping patients; they’re also paving the way to make this approach more accessible for everyone. If you’re ready to rethink depression treatment, this episode is for you. ~DrKF
Check out the show notes at https://tinyurl.com/2t55s3y3 for the full list of links and resources.
GUEST DETAILS
Dr. Achina Stein DO, IFMCP and Silvia Covelli, creator of Healing Depression Project
Website: https://www.healingdepressionproject.com/
Schedule a free call with Silvia or Dr. Stein at: https://tinyurl.com/2z3dxtv7
NOW ACCEPTING APPLICATIONS
The team at Healing Depression Project is thrilled to announce an upcoming 45-Day Depression Recovery Program starting on March, 2025.
The program includes a 30-day in-person retreat at a deluxe and serene ranch in Austin, TX, followed by a 15-day at-home integration phase, ensuring sustainable improvement.
Scholarship Opportunities Available: Participants who are invited to apply can also apply for a scholarship program. If a scholarship is awarded, it can cover up to 80% of the total investment. Schedule a call for details: https://tinyurl.com/2z3dxtv7
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THANK YOU TO OUR SPONSORS
DIAMOND
DUTCH: https://tinyurl.com/4anbz7b3
Biotics Research: https://www.bioticsresearch.com/
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GOLD
OneSkin: http://oneskin.co/DRKARA
TimeLine Nutrition: https://tinyurl.com/bdzx2xms
Vibrant Wellness: https://www.vibrant-wellness.com/
EXCLUSIVE OFFERS FROM OUR SPONSORS
Try QUALIA NAD+ for up to 50% off! Visit https://www.qualialife.com/kara15 and use code KARA15 at checkout for an additional 15% off your entire purchase.
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Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz
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We’re doing a deep dive into NAD, a molecule that has received a lot of attention but still confuses many of us, clinicians included. My guest today is able to unpack the complexities of NAD in a way you’ll find extremely illuminating and useful. I’m excited to have Dr. Greg Kelly Senior Director of Product Development at Qualia, back with us, explaining how NAD is foundational for energy, longevity, and overall cellular health. Dr. Kelly brings clarity to how NAD influences mitochondrial function, DNA repair, and pretty much all of the hallmarks of aging. Yet, problematically, it declines as we age. This episode will cover different NAD compounds, how deficiency might present clinically, and how to measure NAD reliably. Have a listen and get ready to expand your understanding around this essential compound. ~DrKF
Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.
GUEST DETAILS
Dr. Greg Kelly
greg@neurohacker.com
Dr. Greg Kelly is Senior Director of Product Development at Neurohacker Collective, naturopathic physician (N.D.), and author of the book Shape Shift. He was the editor of the journal Alternative Medicine Review and has been an instructor at the University of Bridgeport in the College of Naturopathic Medicine, where he taught classes in Advanced Clinical Nutrition, Counseling Skills, and Doctor-Patient Relationships. Dr. Kelly has published hundreds of articles on natural medicine and nutrition, contributed three chapters to the Textbook of Natural Medicine, and has more than 30 journal articles indexed on Pubmed. His areas of expertise include nootropics, anti-aging and regenerative medicine, weight management, sleep and the chronobiology of performance and health.
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Interesting that research on #lectins and immune reactivity are about to be published. 28:00 #lectins and corresponding #agglutination measured by #rheumatoidFactor 35:10 In people who are sensitive to #lectins, #lectins are not associated with all types of autoimmunity. Joint autoimmunity is associated with #lectins, but myelin autoimmunity is not.